期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 76, 期 10, 页码 838-847出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jnen/nlx076
关键词
ERK inhibitors; Extracellular regulated kinase; Glioblastoma
资金
- Rhoen Klinikum AG [FL_35_2016]
Glioblastoma (GBM) is the most common malignant primary brain tumor. It still carries a grim prognosis and new therapies are needed. This review summarizes the current status of mechanistic insights into the function of extracellular regulated kinase (ERK) and its potential as a therapeutic target for patients with GBM. Currently, some promising ERK inhibitors are in clinical trials in tumor entities other than GBM. Here, we provide a comprehensive overview on the functions of ERK1/2 in GBM and a rationale for treatment of GBM with ERK inhibitors.
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