期刊
BIOACTIVE MATERIALS
卷 4, 期 -, 页码 17-21出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2018.11.002
关键词
Implants; Red phosphorus; Near-infrared; Osteogenesis; Antibacterial; Biofilm
资金
- National Key R&D Program of China [2016YFC1100600, 2016YFC1100604]
- National Natural Science Foundation of China [51671081, 51871162, 51801056, 51422102]
- Natural Science Fund of Hubei Province [2018CFA064]
Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment in vivo. Thus, the development of novel implant materials is quite urgent. Red phosphorus has great biocompatibility and exhibits efficient photothermal ability. Herein, a red phosphorus/IR780/arginine-glycine-asparticacid-cysteine (RGDC) coating on titanium bone-implant was prepared. The temperature sensitivity of Staphylococcus aureus biofilm is enhanced in the presence of ROS produced by IR780 with 808 nm light irradiation. With keeping the cells and tissues normal, a high antibacterial performance can be realized by near-infrared (808 nm) irradiated within 10 min at 50 degrees C. Besides the high effective antibacterial efficacy provided by photothermal therapy (PTT) and photodynamic therapy (PDT), the RGDC decorated surface can also possess an excellent performance in osteogenesis in vivo.
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