期刊
JOURNAL OF NEUROLOGY
卷 264, 期 10, 页码 2088-2094出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-017-8596-7
关键词
Neuromyelitis optica; Aquaporin-4 antibodies; Myelin oligodendrocytes glycoprotein
资金
- MRC [G116/194] Funding Source: UKRI
- National Institutes of Health Research (NIHR) [EME/12/205/28] Funding Source: National Institutes of Health Research (NIHR)
- Medical Research Council [G116/194] Funding Source: Medline
- Department of Health [EME/12/205/28, IS-HPU-1112-10117, RP-PG-0108-10048] Funding Source: Medline
- Medical Research Council [G116/194] Funding Source: researchfish
- National Institute for Health Research [RP-PG-0108-10048, 12/205/28, IS-HPU-1112-10117, NF-SI-0514-10177] Funding Source: researchfish
Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been described in patients with neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 antibodies (AQP4-IgG). We aimed to identify the proportion of AQP4-IgG-negative NMOSD patients who are seropositive for MOG-IgG. In a cross sectional study, we reviewed all patients seen in the National NMO clinic over the last 4 years (after the availability of MOG-IgG testing), including clinical information, MRI, and antibody tests. 261 unique patients were identified. 132 cases satisfied the 2015 NMOSD diagnostic criteria. Of these, 96 (73%) were AQP4-IgG positive and 36 (27%) were AQP4-IgG negative. These 36 patients were tested for MOG-IgG and 15/36 (42%) tested positive. 20% (25/125) of the patients who did not satisfy NMOSD criteria had MOG-IgG. Approximately half of seronegative NMOSD is MOG-Ig seropositive and one in five of non-NMOSD/non-MS demyelination is MOG-IgG positive. Since MOG-associated demyelinating disease is likely different from AQP4-IgG disease in terms of underlying disease mechanisms, relapse risk and possibly treatment, testing for MOG-IgG in patients with AQP4-IgG-negative NMOSD and other non-MS demyelination may have significant implications to management and clinical trials.
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