期刊
BIOACTIVE MATERIALS
卷 4, 期 -, 页码 160-166出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2019.03.002
关键词
Hydrogel; Magnetism-responsive; Tissue injury; Tetra-PEG/agar
资金
- NSFC [51573195]
- Program of transformation medicine of PLA General Hospital [2016TM-039]
Soft tissue injury is very common and associated with pain, tissue swelling and even malformation if not treated on time. Treating methods include cryotherapy, electrical therapy, ultrasound therapy and anti-inflammatory drug, but none of them is completely satisfying. In this work, for a better therapeutic effect, drug therapy and pulsed electromagnetic field (PEMF) therapy were combined. We constructed a drug delivery system using the tetra-PEG/agar hydrogel (PA). By incorporating Fe3O4 NPs into the hydrogel network, a magnetism-responsive property was achieved in the system. The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe3O4 hydrogel. A magnetism-controlled release was attained by the incorporation of Fe3O4. Finally, in vivo study showed a better performance of the DS-loaded PA/Fe3O4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue. Therefore, this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury.
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