期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 308, 期 -, 页码 50-64出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2017.03.001
关键词
Zika virus; Flavivirus; Arbovirus; Mosquito-borne pathogen; Zika outbreak; Zika pandemic; Microcephaly; Guillain-Barre syndrome
资金
- Utah Science Technology and Research Initiative (USTAR) [A34637, A36815]
- American Board of Obstetrics and Gynecology [200784-00001]
- American College of Obstetricians and Gynecologists
- American Society for Reproductive Medicine
- Society for Reproductive Endocrinology and Infertility
Zika virus (ZIKV), a mosquito-borne positive-stranded RNA virus of the family Flaviviridae (genus Flavivirus), is now causing an unprecedented large-scale outbreak in the Americas. Historically, ZIKV spread eastward from equatorial Africa and Asia to the Pacific Islands during the late 2000s to early 2010s, invaded the Caribbean and Central and South America in 2015, and reached North America in 2016. Although ZIKV infection generally causes no symptoms or only a mild self-limiting illness, it has recently been linked to a rising number of severe neurological diseases, including microcephaly and Guillain-Barre syndrome. Because of the continuous geographic expansion of both the virus and its mosquito vectors, ZIKV poses a serious threat to public health around the globe. However, there are no vaccines or antiviral therapies available against this pathogen. This review summarizes a fast-growing body of literature on the history, epidemiology, transmission, and clinical presentation of ZIKV and highlights the urgent need for the development of efficient control strategies for this emerging pathogen. (C) 2017 The Authors. Published by Elsevier B.V.
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