期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 307, 期 -, 页码 14-17出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.03.013
关键词
Multiple sclerosis; Natalizumab; Post-mortem; Histopathology; Epstein-Barr virus; Cytotoxic T lymphocytes
资金
- Italian Ministry of Health [RF-2011-02347228]
Rebound of disease activity in multiple sclerosis patients after natalizumab withdrawal is a potentially life threatening event. To verify whether highly destructive inflammation after natalizumab withdrawal is associated with Epstein-Barr virus (EBV) reactivation in central nervous system infiltrating B-lineage cells and cytotoxic immunity, we analyzed post-mortem brain tissue from a patient who died during a fulminating MS relapse following natalizumab withdrawal. Numerous EBV infected B cells/plasma cells and CD8 + T cells infiltrated all white matter lesions; the highest frequency of EBV lytically infected cells and granzyme B + CD8 + T cells was observed in actively demyelinating lesions. These results may encourage switching to B-cell depleting therapy after natalizumab discontinuation. (C) 2017 Elsevier B.V. All rights reserved.
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