期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 331, 期 -, 页码 74-86出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.10.008
关键词
Microglia; Brain; CD16/32; CD86; CD206; Ym1; Amoeboid
资金
- Japan Society for the Promotion of Science [16K07027, 16J10225]
- Grants-in-Aid for Scientific Research [16J10225, 26430071, 17K07110] Funding Source: KAKEN
Microglia are the primary resident immune cells of the brain parenchyma and transform into the amoeboid form in the activated state under pathological conditions from the ramified form in the resting state under physiologically healthy conditions. In the present study, we found that microglia in the circumventricular organs (CVOs) of adult mice displayed the amoeboid form with fewer branched cellular processes even under normal conditions; however, those in other brain regions showed the ramified form, which is characterized by well-branched and dendritic cellular processes. Moreover, microglia in the CVOs showed the strong protein expression of the M1 markers CD16/32 and CD86 and M2 markers CD206 and Ym1 without any pathological stimulation. Thus, the present results indicate that microglia in the CVOs of adult mice are morphologically and functionally activated under normal conditions, possibly due to the specialized features of the CVOs, namely, the entry of blood-derived molecules into parenchyma through fenestrated capillaries and the presence of neural stem cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据