期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 303, 期 -, 页码 62-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.12.006
关键词
Chitinase 3-like 1; Interferon-beta; Glatiramer acetate; Biomarkers; Multiple sclerosis
资金
- Fondo de Investigacion Sanitaria (FIS), Ministry of Science and Innovation, Spain
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya, Spain
Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFN beta) and glatiramer acetate (GA). Serum CHI3L1 levels were measured by ELISA in 117 relapsing-remitting MS (RRMS) patients, 76 IFN beta-treated and 41 GA-treated patients. CHI3L1 levels were increased by GA (p = 0.014) but unchanged by IFN beta (p =0.830). CHI3L1 was associated with IFN beta, response and levels were higher in non-responder group (p 0.020), while GA showed no responder effect (p = 0.943). These results suggest a role for CHI3L1 as response biomarker to IFN beta in RRMS patients. (C) 2016 Elsevier B.V. All rights reserved.
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