期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 309, 期 -, 页码 47-50出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2017.05.006
关键词
Natalizumab; Multiple sclerosis; Lymphocytes; CD4; CD8
Although improved, the risk of progressive multifocal leukoencephalopathy is a constant threat for patient affected by multiple sclerosis treated with natalizumab. We performed a 24 months longitudinal study aimed to evaluate the total WBC and lymphocytes subsets modifications and their correlations with anti-JCV antibody index after 1 and 2 years of natalizumab treatment. Natalizumab induced an increase of WBC, total and C19 + lymphocytes together with a decrease of CD3 +, CD4 + T lymphocytes and CD4/CD8 ratio, which was positively related to anti-JCV antibodies index at month 0, 12 and 24. Our study confirms that lymphocytes subsets are modified under NAT therapy. Implications of lymphocyte subsets alterations in the pathogenesis of PML are under analyses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据