期刊
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
卷 13, 期 1, 页码 90-99出版社
SPRINGER
DOI: 10.1007/s11481-017-9763-4
关键词
Major depressive disorder; Depression; Transitional B cells; Regulatory B cells; Immunoregulation; Immune response; Immune cells; Immune system
资金
- DFG Cells in Motion-Cluster of Excellence, Munster, Germany [EXC 1003, FF-2014-01]
- German Research Foundation (DFG) [FOR2107 DA1151/5-1, SFB-TRR58]
- Interdisciplinary Center for Clinical Studies (IZKF) [Dan3/012/17]
Pro-inflammatory activity and cell-mediated immune responses have been widely observed in patients with major depressive disorder (MDD). Besides their well-known function as antibody-producers, B cells play a key role in inflammatory responses by secreting pro- and anti-inflammatory factors. However, homeostasis of specific B cell subsets has not been comprehensively investigated in MDD. In this study, we characterized circulating B cells of distinct developmental steps including transitional, na < ve-mature, antigen-experienced switched, and non-switched memory cells, plasmablasts and regulatory B cells by multi-parameter flow cytometry. In a 6-weeks follow-up, circulating B cells were monitored in a small group of therapy responders and non-responders. Frequencies of na < ve lgD(+)CD27(-) B cells, but not lgD(+)CD27(+) memory B cells, were reduced in severely depressed patients as compared to healthy donors (HD) or mildly to moderately depressed patients. Specifically, B cells with immune-regulatory capacities such as CD1d(+)CD5(+) B cells and CD24(+)CD38(hi) transitional B cells were reduced in MDD. Also Bm1-Bm5 classification in MDD revealed reduced Bm2' cells comprising germinal center founder cells as well as transitional B cells. We further found that reduced CD5 surface expression on transitional B cells was associated with severe depression and normalized exclusively in clinical responders. This study demonstrates a compromised peripheral B cell compartment in MDD with a reduction in B cells exhibiting a regulatory phenotype. Recovery of CD5 surface expression on transitional B cells in clinical response, a molecule involved in activation and down-regulation of B cell responses, further points towards a B cell-dependent process in the pathogenesis of MDD.
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