期刊
JOURNAL OF NEUROGENETICS
卷 31, 期 4, 页码 300-306出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/01677063.2017.1390572
关键词
Androgen receptor; aromatase; estradiol; estrogen receptors; neurogenin 3; neuritogenesis
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT), Argentina [PICT 2015 1333]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Argentina (PIP)
- Secretaria de Investigacion, Ciencia y Tecnologia, Universidad de Cordoba (SECyT-UNC), Argentina
- Programa CSIC de Cooperacion Cientifica para el Desarrollo I-COOP [COOPA20038]
- Ministerio de Economia, Industria y Competitividad, Spain [BFU2014-51836-C2-1-R]
- Centro de Investigacion Biomedica en Red de Fragilidad y Envejecimiento Saludable [CIBERFES], Instituto de Salud Carlos III, Madrid, Spain [CB16/10/00383]
- Fondos FEDER
Female mouse hippocampal and hypothalamic neurons growing in vitro show a faster development of neurites than male mouse neurons. This sex difference in neuritogenesis is determined by higher expression levels of the neuritogenic factor neurogenin 3 in female neurons. Experiments with the four core genotype mouse model, in which XX and XY animals with male gonads and XX and XY animals with female gonads are generated, indicate that higher levels of neurogenin 3 in developing neurons are determined by the presence of the XX chromosome complement. Female XX neurons express higher levels of estrogen receptors than male XY neurons. In female XX neurons, neuronal derived estradiol increases neurogenin 3 expression and neuritogenesis. In contrast, neuronal-derived estradiol is not able to upregulate neurogenin 3 in male XY neurons, resulting in decreased neuritogenesis compared to female neurons. However, exogenous testosterone increases neurogenin 3 expression and neuritogenesis in male XY neurons. These findings suggest that sex differences in neuronal development are determined by the interaction of sex chromosomes, neuronal derived estradiol and gonadal hormones.
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