期刊
JOURNAL OF NEUROCHEMISTRY
卷 142, 期 -, 页码 111-121出版社
WILEY
DOI: 10.1111/jnc.14052
关键词
ACh; AD; cholinergic; hippocampus; learning; memory; muscarinic; nicotinic
资金
- NIEHS/NIH intramural research program [Z01-ES090089]
Acetylcholine (ACh) plays an important role in memory function and has been implicated in aging-related dementia, in which the impairment of hippocampus-dependent learning strongly manifests. Cholinergic neurons densely innervate the hippocampus, mediating the formation of episodic as well as semantic memory. Here, we will review recent findings on acetylcholine's modulation of memory function, with a particular focus on hippocampus-dependent learning, and the circuits involved. In addition, we will discuss the complexity of ACh actions in memory function to better understand the physiological role of ACh in memory.
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