期刊
JOURNAL OF NEUROCHEMISTRY
卷 141, 期 5, 页码 750-765出版社
WILEY
DOI: 10.1111/jnc.14029
关键词
AMD; HO-1; light-induced retinal degeneration; Nrf2; photoreceptor; retina
资金
- Daiichi Sankyo Co., Ltd.
- Gifu Pharmaceutical University
- Grants-in-Aid for Scientific Research [15J07651, 16K11325] Funding Source: KAKEN
The retina is highly sensitive to oxidative stress because of its high consumption of oxygen associated with the phototransductional processes. Recent findings have suggested that oxidative stress is involved in the pathology of age-related macular degeneration, a progressive degeneration of the central retina. A well-known environmental risk factor is light exposure, as excessive and continuous light exposure can damage photoreceptors. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcriptional factor that controls antioxidative responses and phase 2 enzymes. Thus, we hypothesized that RS9, a specific activator of Nrf2, decreases light-induced retinal cell death in vivo and in vitro. Nrf2 was detected in the nucleus of the 661W cells exposed to RS9 and also after light exposure, and the Nrf2-antioxidant response element binding was increased in 661W cells after exposure to
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