期刊
JOURNAL OF NEURO-ONCOLOGY
卷 137, 期 2, 页码 357-365出版社
SPRINGER
DOI: 10.1007/s11060-017-2725-0
关键词
Estrogen; Glioma; Risk assessment; Meta-analysis
资金
- National Natural Science Foundation of China [81372714, 81672480]
- Liaoning Provincial Natural Science Foundation of China [201602244]
- Distinguished Professor Project of Liaoning Province
- Special Grant for Translational Medicine, Dalian Medical University [2015002]
Various studies have confirmed the important roles of endogenous hormones in the development of gliomas, while the roles of exogenous hormones remain controversial. Based on case-control studies and cohort studies, a meta-analysis was exerted to explore the effect of two exogenous hormones use (HRT: hormone replacement therapy; OC: oral contraceptives) on glioma risk. 16 eligible studies, including 11 case-control studies and 5 cohort studies, containing 8055027 women, were included in our study. All included studies have reported the relative risks (RRs) or odds ratios (ORs), and 95% confidence intervals (CIs). We use the fixed-effects model to calculate the estimated overall risk. In case-control studies, the risk of glioma was lower in women who had ever been treated with an exogenous hormone than in the control group (HRT: OR 0.91, 95% CI 0.84-0.99; OC: OR 0.99, 95% CI 0.91-1.07). In research of cohort studies, similar results have been obtained (HRT: RR 0.95, 95% CI 0.83-1.08; OC: RR 0.75, 95% CI 0.66-0.84). Our study further confirmed that the use of exogenous hormones has an important impact on the risk of glioma in women. However, more prospective studies are needed to further confirm this conclusion.
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