期刊
RSC ADVANCES
卷 9, 期 59, 页码 34671-34676出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra06724h
关键词
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资金
- National Natural Science Foundation of China [81673306, 81703348, 81874289]
- China Pharmaceutical University
- Early Career Scheme of the Research Grants Council of Hong Kong [25100017]
- Double First-Class University project [CPU2018GY04, CPU2018GY35]
N-(Pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines were synthesized respectively from alpha-bromoketones and 2-aminopyridine under different reaction conditions. N-(Pyridin-2-yl)amides were formed in toluene via C-C bond cleavage promoted by I-2 and TBHP and the reaction conditions were mild and metal-free. Whereas 3-bromoimidazopyridines were obtained in ethyl acetate via one-pot tandem cyclization/bromination when only TBHP was added, the cyclization to form imidazopyridines was promoted by the further bromination, no base was needed, and the versatile 3-bromoimidazopyridines could be further transferred to other skeletons.
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