期刊
IMMUNE NETWORK
卷 19, 期 5, 页码 -出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2019.19.e36
关键词
Mesenchymal stem cells; Inflammation; Podocytes; Fibrosis
类别
资金
- National Research Foundation of Korea (NRF) - Korea Government [NRF-2017R1A5A2015541, NRF-2017M3A9B4050336]
- National Research Foundation of Korea [2017M3A9B4050336] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Mesenchymal stem cells (MSCs) ameliorate the renal injury in Adriamycin (ADR)-induced nephropathy, but the mechanisms underlying their efficacy remain incompletely understood. In this study, we demonstrated that MSCs increased the survival, recovered body weight loss, and decreased proteinuria and serum creatinine levels in ADR-treated mice. MSCs also prevented podocyte damage and renal fibrosis by decreasing the expression of fibronectin, collagen 1 alpha 1, and alpha-smooth muscle actin. From a mechanistic perspective, MSCs inhibited renal inflammation by lowering the expression of CCL4, CCL7, CCL19, IFN-alpha/beta, TGF-beta, TNF-alpha, and chitinase 3-like 1. In summary, our data demonstrate that MSCs improve renal functions by inhibiting renal inflammation in ADR-induced nephropathy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据