期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 6, 页码 1703-1713出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00703
关键词
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资金
- University of Lodz [506/1136]
The methanol extract of the leafy covers of Corylus avellana, source of the Italian PGI (protected geographical indication) product Nocciola di Giffoni, afforded two new cyclic: diarylheptanoids, giffonins T and U (2 and 3), along with two known cyclic diarylheptanoids, a quinic acid, flavonoid-, and citric acid derivatives. The structures of giffonins T and U were determined as highly hydroxylated cyclic diarylheptanoids by 1D and 2D NMR experiments. Their relative configurations were assigned by a combined quantum mechanical/NMR approach, comparing the experimental C-13/H-1 NMR chemical shift data and the related,predicted values. The absolute configurations of carpinontriol B (1) and giffonins T and U (2 and 3) were assigned by comparison of their experimental electronic circular dichroism curves with the TDDFT-predicted curves. The ability of the compounds to inhibit the lipid peroxidation induced by H2O2 and H2O2/Fe2+ was determined by measuring the concentration of thiobarbituric acid reactive substances. Furthermore, the antimicrobial activity of the methanol extract of leafy covers of C. avellana and of the isolated compounds against the Gram-positive strains Bacillus cereus and Staphylococcus aureus and the Gram-negative strains Escherichia coli and Pseudomonas aeruginosa was evaluated. Carpinontriol B (1) and giffonin U (3) at 40 mu g/disk caused the formation of zones of inhibition.
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