期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 2, 页码 278-289出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00643
关键词
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资金
- Ministerio de Economia y Competitividad (MINECO) [SAF2014-57094-R]
- Ramon y Cajal program [RYC-2011-07987]
- Generalitat de Catalunya (GC) [2014SGR938, 2014SGR1189]
- Ramon y Cajal program of MICINN [RYC-2011-07987]
- Juan de la Cierva program of MINECO [JCI-2012-12193]
- Icrea Academia
Alzheimer's disease (AD) is the main cause of dementia in people over 65 years. One of the major culprits in AD is the self-aggregation of amyloid-beta peptide (Afi), which has stimulated the search for small molecules able to inhibit Afi aggregation. In this context, we recently reported a simple, but effective in vitro cell-based assay to evaluate the potential antiaggregation activity of putative A beta aggregation inhibitors. In this work this assay was used together with docking and molecular dynamics simulations to analyze the anti-A beta aggregation activity of several naturally occurring flavonoids and phenolic compounds. The results showed that rosmarinic acid, melatonin, and o-vanillin displayed zero or low inhibitory capacity, curcumin was found to have an intermediate inhibitory potency, and apigenin and quercetin showed potent antiaggregation activity. Finally, the suitability of the combined in vitro cell-based/in silico approach to distinguish between active and inactive compounds was further assessed for an additional set of flavonols and dihydroflavonols.
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