期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 2, 页码 551-559出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b01146
关键词
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资金
- National Natural Science Foundation of China [81172958]
- Basic Research Subject of Key Laboratory - Educational Commission of Liaoning Province of China [LZ2014044]
- China Scholarships Council
Investigation of the alkaloids from Peganum harmala seeds yielded two pairs of unique racemic pyrroloindole alkaloids, (+/-)-peganines A-B (1-2); two rare thiazole derivatives, peganumals A-B (3-4); six new)beta-carboline alkaloids, pegaharmines F-K (5-10); and 12 known analogues. Their structures, including stereochemistry, were elucidated through spectroscopic analyses, quantum chemistry calculations, and single-crystal X-ray diffraction. Notably, the incorporation of pyrrole and indole moieties in peganines A-B, thiazole fragments in peganumals A-B, and a C-1 alpha,beta-unsaturated ester motif in pegaharmine F (5) are all rare, and their presence in the genus Peganum were demonstrated for the first time. All isolates were tested for antiproliferative activities against the HL-60, PC-3, and SGC-7901 cancer cell lines, and compounds 9, 11, 12, and 13 exhibited moderate cytotoxicity against HL-60 cancer cell lines with IC50 values in the range of 4.36-9.25 mu M.
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