期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 3, 页码 771-781出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b01167
关键词
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资金
- National Cancer Institute [R01CA163287]
- National Institutes of Health [P20GM1 0 3 541, P20GM1 043 1 6, P30GM1 1 0 7 5 8, SI0RR02692, S10OD016267]
- Department of Health and Human Services
- NSF [CHE0421224, CHE1229234, CHE0840401]
- NIS
In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.
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