期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 6, 页码 1734-1741出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00954
关键词
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资金
- National Natural Science Foundation of China [21275075, 31500278, 61605084]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [13KJB360002]
An investigation of the potential neuroprotective natural product constituents of the rhizomes of Typhonium giganteum led to the isolation of two new cerebrosides, typhonosides E (1) and F (2), along with 11 known analogues (3-13). The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. The activity of these compounds against glutamate-induced cell apoptosis was investigated in PC12 cells. All compounds exhibited such activity, which was related to the length of the fatty acyl chain. Among them, longan cerebroside II (11), with the longest fatty aryl chain, showed the most potent protective effect in PC12 cells from glutamate injury, with an EC50 value of 2.5 mu M. Moreover, at the molecular level, longan cerebroside II (11) downregulated the expression of caspase-9, caspase-3, and Box, upregulated the expression of Bcl-2, and decreased the level of cytosolic cytochrome c in a concentration-dependent manner.
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