期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 3, 页码 475-483出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00579
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资金
- National Center for Complementary and Integrative Health [1 R01 AT008088]
- National Science Foundation [CHE-0619382, CHE-0722638]
Nine new compounds containing either a chromane or chromene ring moiety were isolated from the monotypic plant Koeberlinia spinosa. Compounds 1-4 are chromanes with all possible E and Z isomers of the isoprenoid side chain, with compound 5 a methylated derivative of 1. Compounds 6 and 7 were assigned as diastereomeric cyclized derivatives of 2 and were probably artifacts formed during the extraction or the isolation processes. Compounds 8 and 9 were characterized as new chromenes. Structure elucidation of 1-9 was conducted via 1D and 2D NMR spectroscopic data interpretation, and absolute configurations were determined by ECD spectroscopic analysis. Compounds 2, 5, 6, and 7 had weak antiplasmodial activity, while none of the compounds exhibited antiproliferative activity. The isolation, structure elucidation, and biological evaluation of these compounds are presented.
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