期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 5, 页码 1248-1254出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00786
关键词
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资金
- National Natural Science Foundation of China [81503201, 81473334]
- Dalian Outstanding Youth Science and Technology Talent awards [2014J11JH132, 2015J12JH201]
- Distinguished Professor of Liaoning Province, Liaoning Bai Qian Wan Talents Program
- Innovation Team of Dalian Medical University
An investigation on the bioactive chemical constituents of the roots of Euphorbia fischeriana has been conducted, with 21 diterpenoids obtained using various chromatographic techniques. On the basis of spectroscopic data analysis, the new compounds were elucidated as four ent-abietane-type diterpenoids (1-4) and four tigliane-type diterpenoids (13-16). Also obtained were eight known ent-abietane (5-12) and five known tigliane (17-21) diterpenoids. The potential antituberculosis effects of these diterpenoids were evaluated using a Mycobacterium smegmatis model. The most potent compound according to the in vitro bioassay used was 17-hydroxyjolkinolide B (12) (MIC 1.5 mu g/mL).
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