期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 12, 页码 3325-260出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00853
关键词
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资金
- Marie-Clement Rodier
- C.S.Sp. Endowed Chair fund
Oxyprenylated compounds (i.e., ferulic acid and coumarin derivatives) demonstrate neuroprotection and anticancer properties as reported in previous studies. We have tested the affinity of oxyprenylated ferulic acid (1-4) and umbelliferone derivatives (5-11) to melatonin receptors as well as their antiproliferation and antimigratory properties against breast cancer (BC) cell lines. All the compounds except for ferulic acid, boropinic acid, and umbelliferone had binding affinities to melatonin receptors in the nM to mu M range, and both auraptene and umbellinprenin reduced BC cell proliferation and migration in phenotypically diverse BC including triple negative.
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