期刊
FOOD SCIENCE AND TECHNOLOGY RESEARCH
卷 25, 期 1, 页码 107-113出版社
JAPANESE SOC FOOD SCI & TECHNOLOGY
DOI: 10.3136/fstr.25.107
关键词
D-glucosamine; serum; cecum; ammonia; ethanol; microflora; bacterial overgrowth
资金
- Funds for the Development of Human Resources in Science and Technology under the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan through the Home for Innovative Researchers and Academic Knowledge Users (HIRAKU) consortium, Hiro
D-Glucosamine (GlcN) has been widely consumed as a dietary supplement because of its health benefits. However, limited information exists on the adverse effects of high-dose GlcN treatment. In this study, we investigated the effect of dietary 4 % GlcN hydrochloride on serum and cecum parameters in rats. Growth and food intake were unaffected, but serum levels of ammonia and ethanol significantly increased by GlcN (+21 % and +12 %, respectively). No changes in serum parameters, including AST, ALT, LDH, gamma-GTP (indices of liver damage), and urea, were found. The GlcN intake significantly increased the weights of cecal contents (+115 %). Furthermore, supplemental GlcN significantly elevated the levels of ammonia and ethanol (+27 % and +93 %, respectively) and the number of total bacteria (+79 %), when expressed per gram of cecal contents. Our results suggest that high-dose GlcN causes adverse effects by increasing ammonia and ethanol levels and by bacterial overgrowth.
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