期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 10, 页码 2677-2683出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00383
关键词
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资金
- Natural Sciences and Engineering Council of Canada (NSERC)
- Canada Research Chair Program
- Atlantic Canada Opportunities Agency
- Canada Foundation for Innovation
- Nautilus Biosciences Canada Inc.
- Innovation PEI
- Jeanne and Jean-Louis Levesque Foundation
Four new cyclic heptapeptides, mortiamides A-D (1-4), were obtained from a novel Mortierella sp. isolate obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry. The absolute configurations of the amino acids were determined using Marfey's method. Localization of L and D amino acids within each compound was ascertained by retention time comparison of the partial hydrosylate products of each compound to synthesized dipeptide standards using LC-HRMS. Compounds 1-4 did not exhibit any significant antimicrobial or cytotoxic activity.
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