期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 9, 页码 2551-2555出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00328
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资金
- University of Wisconsin Madison School of Pharmacy
- NIH [U19 AI109673, P41RR02301, P41GM66326]
Here we describe the rapid identification and prioritization of novel active marine natural products using an improved dereplication strategy. During the course of our screening of marine natural product libraries, a new cyclic trihydroxamate compound, thalassosamide, was discovered from the alpha-proteobacterium Thalassospira profundimaris. Its structure was determined by 2D NMR and MS/MS experiments, and the absolute configuration of the lysine derived units was established by Marfey's analysis, whereas that of C-9, 9', and 9 '' was determined via the circular dichroism data of the [Rh-2(OCOCF3)(4)] complex and DFT NMR calculations. Thalassosamide showed moderate in vivo efficacy against Pseudomonas aeruginosa.
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