期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 7, 页码 2060-2066出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00255
关键词
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资金
- German Academic Exchange Service (DAAD) through the Natural Products Research Network for Eastern and Central Africa (NAPRECA)
- Swedish Research Council [201605857]
- Academy of Finland [263256, 265328, 292746]
- University of Jyvaskyla
- Royal Society of Arts and Sciences in Goteborg
A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 mu M, respectively.
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