期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 11, 页码 3025-3031出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00660
关键词
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资金
- National Research Council of Science & Technology (NST) - International Joint Research Project [ASIA-16-001]
- KRIBB Research Initiative Program of Korea
- National Research Foundation of Korea (NRF) - Korean government (MSIT
- Ministry of Science ICT) [NRF-2017R1C1B2002602]
Analysis of the genome sequence of Streptomyces sp. KCB13F003 showed the presence of a cryptic gene cluster encoding flavin-dependent halogenase and nonribosomal peptide synthetase. Pleiotropic approaches using multiple culture media followed by LC-MS-guided isolation and spectroscopic analysis enabled the identification of two new chlorinated cyclic hexapeptides, ulleungmycins A and B (1 and 2). Their structures, including absolute configurations, were determined by 1D and 2D NMR techniques, advanced Marfey's analysis, and GITC derivatization. The new peptides, featuring unusual amino acids 5-chloro-L-tryptophan and D-homoleucine, exhibited moderate antibacterial activities against Gram-positive pathogenic bacteria including methicillin-resistant and quinolone-resistant Staphylococcus aureus.
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