Organocatalytic enantioselective conjugate addition of pyrazolin-5-ones to arylomethylidene malonates

An efficient asymmetric organocatalytic conjugate addition reaction of pyrazolin-5-ones with arylomethylidene malonates has been successfully developed by employing bifunctional Cinchona derived thiourea organocatalysts. The protocol provides straightforward access to pyrazole substituted scaffolds in good yields with high stereocontrol.