期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 7, 页码 2094-2100出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00327
关键词
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资金
- Scientific and Technological Research Council of Turkey (TUBITAK) [1059B141400648]
- Department of Scientific Research Projects of Istanbul Technical University [40258]
- AFPE Predoctoral Fellowship in Pharmaceutical Sciences
- NIH Shared Instrumentation Grant [S10RR024664]
- NSF Major Research Instrumentation Grant [0320648]
- [DA018151]
- [GM111385]
- [GM008545]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1625923] Funding Source: National Science Foundation
Columbin (1) is a furanolactone diterpene isolated from the roots of Jateorhiza and Tinospora species. These species generally grow in Asia and Africa and have been used in folk medicine for their apparent analgesic and antipyretic activities. Columbin (1) is of particular interest due to its structural similarity to the known kappa-opioid receptor (KOR) agonist salvinorin A. Given that the KOR is of interest in the study of many serious diseases, such as anxiety, depression, and drug addiction, obtaining natural or semisynthetic molecules with KOR activity recently has gained much interest. For this reason, in the present study, derivatives of 1 were designed and synthesized using known structure-activity relationships of salvinorin A at KORs. The structures of the columbin analogues prepared were elucidated by NMR spectroscopy and mass spectroscopy, and their KOR activity was investigated in vitro by inhibition of forskolin-induced CAMP accumulation. Slight improvements in KOR activity were observed in columbin derivatives over their parent compound. However, despite the structural similarities to salvinorin A, neither columbin (1) nor its derivatives were potent KOR ligands. This work represents not only the first evaluation of columbin (1) at the KOR but also one of the first works to explore synthetic strategies that are tolerated on the columbin core.
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