期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 10, 页码 2699-2707出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00438
关键词
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资金
- National Natural Science Foundation of China [81573312]
- National Key Technology R&D Program New Drug Innovation of China [2017ZX09101003-006-009]
- Graduate Independent Project in Beijing University of Chinese Medicine [2015-JYB-XS059]
- Grants-in-Aid for Scientific Research [26303005, 16H06443, 15H01836] Funding Source: KAKEN
Eight new chrysogenolides (A-H (1-8)) and seven known (9-15) 3,5-dimethylorsellinic acid derived meroterpenoids were isolated from the solid substrate fermentation cultures of a Huperzia serrata endophytic fungus, Penicillium chrysogenum MT-12. The structures of the new compounds were elucidated by interpretation of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of 1-4 were determined by single-crystal X-ray crystallographic analysis, and those of 5-8 were assigned on the basis of experimental and calculated electronic circular dichroism spectra. Compounds 3, 4, 6, 11, and 12 showed inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophage cells with IC50 values in the range of 4.3-78.2 mu M (positive control, indomethacin, IC50 = 33.6 +/- 1.4 mu M).
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