期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 5, 页码 1668-1673出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00269
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资金
- NSFC [81425022, U1501223, 81572037]
- CAS [XDA11030403]
- Guangdong NSF [2016A030312014]
Emodacidamides A H (1-8), natural products featuring anthraquinone amino acid conjugates, have been isolated from a marine-derived fungus, Penicillium sp. SCSIO sof101, together with known anthraquinones 9 and 10. The planar structures of 1-8 were elucidated using a combination of NMR spectroscopy and mass spectrometry. The absolute configurations of the amino acid residues were confirmed using Marfey's method and chiral-phase HPLC analyses. Additionally, isolates were evaluated for possible immunomodulatory and cytotoxic activities. Emodacidamides A (1), C (3), D (4), and E (5) cells with IC50 values of 4.1, 5.1, 12, and 5.4 mu M, respectively.
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