期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 88, 页码 13267-13270出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc07009e
关键词
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资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2018R1A3B1052702, NRF-2019M3E5D1A01068998]
- Basic Science Research Program - Ministry of Education [2017R1D1A1-B03030062]
- Korea Basic Science Institute Grant [T38662]
- National Research Foundation of Korea [2017R1D1A1B03030062] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
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