期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 17, 期 1, 页码 196-202出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2017.12444
关键词
Zinc Oxide; Nanoparticles; Cytotoxicity; Prostate Cells; Cancer
类别
资金
- National Natural Science Foundation of China [61201100]
- University Creative Group Project of Hunan Education Department
- Economical Forest Cultivation and Utilization of Collaborative Innovation Center in Hunan Province [(2013) 448]
Despite increasing biomedical applications of zinc oxide nanoparticles (ZnO NPs), there is a lack of information concerning the biological effects of ZnO NPs on human cells. The purpose of this study was to assess the comparative cytotoxicity in human prostate cells (PC-3 and RWPE-1) exposure to 20-nm ZnO NPs. Exposure to concentrations from 0 to 50 mu g/mL of ZnO NPs reduced cell viability of PC-3 cells in a dose-and time-dependent manner; whereas it did not affect RWPE-1 cells. A dose-dependent increase in LDH leakage and intracellular reactive oxygen species was observed in PC-3 cells but not in RWPE-1 cells exposure to ZnO NPs at concentrations of 8 similar to 50 mu g/mL for 24 h (P < 0.05). That the percentage of apoptotic cells increased significantly was observed in PC-3 cells induced by ZnO NPs at 10 mu g/mL exposure for 8 h. Our results showed that ZnO NPs induced in vitro preferential cytotoxicity in the human prostate cancer cells. We indicated that the different cytotoxicity of ZnO NPs is likely due to the different cell-nanoparticle interaction and response behavior rather than to hydrodynamic sizes of particles. It is suggested that ZnO NPs are expected to find a very promising targeting therapeutic application for human prostate cancer.
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