期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 43, 页码 9510-9513出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01796h
关键词
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Nucleophilic addition of Grignard reagents to tetrahydro-beta -carboline (THC) N-sulfonyl N,S-acetal generates exclusively cis-1,3-disubstituted THCs with a unique 1,3-diaxial conformation. The stereochemical relationship of the 1,3-substituents was confirmed by 2-dimensional NMR spectroscopy and X-ray crystallography. The mechanism of the reaction is proposed based on crystal structures and molecular orbital calculations.
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