期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 17, 期 1, 页码 1-17出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2017.12932
关键词
Inorganic Nano-Carriers; Nano-Medicine; Platinum-Based Drugs; Targeted Drug Delivery System; Antitumor Activity; Review
类别
资金
- National Natural Science Foundation of China [21361014, 21302074, 21062009]
- Doctoral Fund of Ministry of Education Fund [20125314120007]
- Natural Science Foundation of Yunnan Province [KKSY201226108]
As one of the most important anticancer drugs, cisplatin and its analogues have been widely used in chemotherapy regimens of various tumors. However, a series of side effects and resistance/cross-resistance have been becoming the main obstacles which limit their application and effectiveness. Recent researches suggest that inorganic nano-materials which act as targeted drug delivery carriers of platinum-based anticancer drugs not only enhance the antitumor activity of platinum-based drugs, but also reduce the side effects and resistance. The nano-targeted drugs delivery system provides a new strategy in clinical application of platinum-based anticancer drugs. This review will focus on recent advances in inorganic nano-carriers for platinum-based targeted drugs delivery system.
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