期刊
DATA IN BRIEF
卷 25, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.dib.2019.103862
关键词
Xenoestrogen; Mammary gland; Puberty; Morphometric; Endocrine disruptor; Two hit model
资金
- National Institute of Environmental Health Sciences of the National Institutes of Health [K22ES025811]
Bisphenol S (BPS) is an analogue of bisphenol A (BPA), used in consumer products including food packaging and thermal paper. Like BPA, BPS is an estrogen receptor agonist and exposures during perinatal development have been shown to alter growth and morphology of the mouse female mammary gland prior to puberty and in adulthood. Reported here are data describing the effect of exposure to low doses of BPS (2, 200 or 2000 mg/kg/day) during perinatal development on morphology and gene expression in the mammary gland of female CD-1 mice, with or without an additional estrogen exposure (1 mg/kg/day ethinyl estradiol) during the peripubertal period. Additional data document other estrogen-sensitive outcomes including timing of vaginal opening and uterine weight. The data suggest that low doses of BPS induce modest changes in the mammary gland at puberty, but do not appear to sensitize the female to an estrogenic challenge administered during the peripubertal period. (c) 2019 The Authors. Published by Elsevier Inc.
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