期刊
JOURNAL OF NANOPARTICLE RESEARCH
卷 19, 期 12, 页码 -出版社
SPRINGER
DOI: 10.1007/s11051-017-4082-5
关键词
Reduction-responsive; Crosslinking; Micelles; Star-shaped copolymers; Click chemistry; Nanomedicine
资金
- National Natural Science Foundation of China [51703209, 21603196]
- Natural Science Foundation of Hubei Province [2017CFB217]
- China University of Geosciences (Wuhan) [CUG170601, CUGL170406]
To improve the stability of polymeric micelles, here we describe interlayer-crosslinked micelles prepared from star-shaped copolymer via click chemistry. The formation of interlayer-crosslinked micelles was investigated and confirmed by proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, and fluorescence spectroscopy. The morphology of un-crosslinked micelles and crosslinkedmicelles observed by transmission electron microscope is both uniform nano-sized spheres (approximately 20 nm). The crosslinking enhances the stability of polymeric micelles and improves the drug loading capacity of polymeric micelles. The interlayer-crosslinked micelles prepared from star-shaped copolymer and a crosslinker containing a disulfide bond are reduction-responsive and can release the drug quickly in the presence of the reducing agents such as glutathione (GSH).
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