期刊
JOURNAL OF NANOPARTICLE RESEARCH
卷 19, 期 12, 页码 -出版社
SPRINGER
DOI: 10.1007/s11051-017-4096-z
关键词
Spinel ferrites; M2+ effect; Mesoporous property; Magnetism; Microwave response; Nanomedicine
资金
- National Natural Science Foundation of China [21071115]
- Education Committee of Shaanxi Province [16JS112]
- Shaanxi Natural Science Foundation Project [2016JZ006]
- Shaanxi Light Optoelectronics Material Co., Ltd. [2015610002001920]
Spinel ferrites can be used in magnetic targeting and microwave heating and can therefore be used for targeted and controllable drug delivery. We used the cetyltrimethylammonium bromide-assisted solvothermal method to synthesize a series of spinel ferrites (MxFe3-xO4, M= Mg, Mn, Fe, Co, Ni, Cu, Zn) with a mesoporous or hollow-mesoporous structure suitable for direct drug loading and the particle diameters ranging from 200 to 350 nm. We investigated the effects of M2+ cation on the morphology and properties of these products by analyzing their transmission electron microscopy images, mesoporous properties, magnetic properties, and microwave responses. We chose hollow-mesoporous MxFe3-xO4 (M= Fe, Co, Zn) nanoparticles, which had better overall properties, for the drug VP16 (etoposide) loading and microwavecontrolled release. The CoxFe3-xO4 and Fe3O4 particles trapped 61.5 and 64.8%, respectively, of the VP16, which were higher than that (60.4%) of ZnxFe3-xO4. Controllable drug release by these simple magnetic nanocarriers can be achieved by microwave irradiation, and VP16-loaded CoxFe3-xO4 released the most VP16 molecules (more than 50% after 1 h and 69.1% after 6 h) under microwave irradiation. Our results confirm the favorable drug loading and microwave-controlled delivery by these ferrites, and lay a theoretical foundation to promote clinical application of the targeted controllable drug delivery system. In the present study, we prepared mesoporous or hollow-mesoporous spinel ferrites (MxFe3-xO4, M= Mg, Mn, Fe, Co, Ni, Cu, Zn) by CTAB-assisted solvothermal method and solved the problem of Cu and Ni impurities in CuxFe3-xO4 and NixFe3-xO4 products by means of magnetic separation and additional redox reactions, respectively. We investigated the effects of the M2+ cation on the morphology, mesoporous properties, magnetic properties, and microwave responses of these ferrites. Then, the drug loading and microwave-controlled drug release of hollow-mesoporous MxFe3-xO4 (M = Fe, Co, Zn) nanoparticles with better overall properties were also studied. CoxFe3-xO4 has the best overall performances for microwave-controlled drug release.
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