期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 85, 页码 12813-12816出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc06356k
关键词
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资金
- National Natural Science Foundation of China [21871254, 21532006]
- DICP [DICP ZZBS201602]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB17000000]
A water promoted asymmetric aldol/lactonization/enolization cascade reaction of alpha-keto acids and alpha-keto esters was developed, affording the first general protocol for the construction of chiral quaternary isotetronic acids with excellent enantioselectivity. Theoretical results indicate that intramolecular ionized enamine intermediates stabilized by water generate zwitterionic transition states in a lower activation energy and higher face selectivity, resulting in high activity and chemo- and enantioselectivity.
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