期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1149, 期 -, 页码 613-625出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2017.08.031
关键词
Moxifloxacin; 2,2 '-bipyridine; IR; Thermal; MDA; TNF-alpha
资金
- Zagazig University, Zagazig, Egypt [442]
The article describes the interaction of Y(III), Zr(IV), La(III), Ce(IV) and U(VI) with moxifloxacin hydrochloride and 2,2'-bipyridine. Characterization of complexes was made by elemental analyses, molar conductivity, magnetic moment measurements and spectral measurements e.g. IR, UV Vis.,H-1 NMR and mass as well as thermal analyses (TG and DTG). The molar conductivity shows that the complexes are electrolytes nature. Spectroscopic investigation of the solid complexes studied here indicate that moxifloxacin hydrochloride and 2,2'-bipyridine are coordinated to the metal ions in a neutral bidentate manner. After complete characterization, the chemical formulae of the complexes were established. The calculated bond length and force constant, F(U center dot center dot center dot 0), in the uranyl complex are 1.756 A and 637.90 Nrn(-1), respectively. Kinetic and thermodynamic parameters were determined using Coats Redfern and Horowitz Metzger equations. Establishment of hydrochloric acid that induce acute lung injury (ALI) in rats by intratracheal administration through damaging the alveolar epithelium and activation of the neutrophil and subsequent oxidative stress by increasing malondialdehyde (MDA), tumor necrosis factor (TNF-alpha) and neutrophil, which were confirmed by histopathological investigation while decreasing in antioxidant enzymes and lymphocytes. Whereas treatment with mixed-ligand metal complexes significantly decrease MDA, TNF-alpha and neutrophils and increase antioxidant and lymphocytes. (C) 2017 Elsevier B.V. All rights reserved.
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