期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1150, 期 -, 页码 459-468出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2017.09.003
关键词
Metal-flavonoid complexes; DFT predictions; Stoichiometry; Chelation sites; Anti-diabetic activity
资金
- URF
- HEC Pakistan [20/1718/RD/HEC]
- Quaid-i-Azam University Islamabad
The current study is aimed at the synthesis of Cu (II) and Fe (III) complexes of three flavonoids {morin (mor), quercetin (quer) and primuletin (prim)} and characterization through UV-Vis spectroscopy, cyclic voltammetry, FTIR, and thermal analysis. Structure prediction through DFT calculation was supported by experimental data. Benesi-Hildebrand equation was modified to function for 1:2 Cu-flavonoid and 1:3 Fe-flavonoid complexes. DFT predictions revealed that out of poly chelation sites present in morin and quercetin, 3-OH site was utilized as preferable chelation site while primuletin chelated through 5-OH position. In-vivo trials revealed the complexes to have better anti-diabetic potential than respective flavonoid. Fls/M-Fls proved as antagonistic to Alloxan induced diabetes and also retained anti-diabetic activity even in the presence of (2-hydroxypropy1)-beta-cycloclextrin (HP beta CD). (C) 2017 Elsevier B.V. All rights reserved.
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