期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 15, 期 13, 页码 2798-2814出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.33779
关键词
Primary immune thrombocytopenia; T helper cells; regulatory T cells; bone marrow
资金
- National Natural Science Foundation of China [81570103, 81500094]
- 973 Program [2015CB755402]
- Wu Jie Ping Medical Foundation [320.6750.17181]
- Science and Technology Development Program of Shandong Province [2013GSF11824]
Disequilibrium of CD4(+) T-cell subpopulations in peripheral blood (PB) of patients with primary immune thrombocytopenia (ITP) has been well established, whereas the profile of CD4(+) T-cell subpopulations in bone marrow (BM) remains elusive. In the present study, the frequencies of T helper 22 (Th22), Th17, Th1, Th2, follicular T helper (Tfh) cells and regulatory T cells (Tregs) as well as their effector cytokines in BM and PB from active ITP patients and healthy controls (HCs) were determined. Results showed that the frequencies of Th22, Th17, Th1, and Tfh cells were significantly higher, but Treg number was remarkably lower in BM from ITP patients than from HCs. In the ITP group, it was notable that the numbers of BM Th22, Th17, Th1, Th2, and Tfh cells were significantly elevated compared with the matched PB counterparts, while Treg number in BM was considerably reduced compared with that in PB. In consistence with the BM Th subset pattern, plasma levels of interleukin (IL)-22, IL-17A, and interferon (INF)-gamma in BM from ITP patients were significantly increased compared with that from HCs. Therefore, the balance of CD4(+) T-cell subsets was disrupted in both BM and PB of ITP patients, suggesting that this might play important roles in the pathophysiological process of ITP.
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