期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 91, 页码 13733-13736出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc07841j
关键词
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资金
- Natural Science Foundation of China [21675072, 21305058, 21705066]
- Shandong Province Higher Educational Science and Technology Program [KJ2018BZC043, ZR2019MB068]
The tough challenges for the convenient and quantitative determination of circulating miRNAs (cmiRNAs) in the peripheral blood are low abundance, high interference and lack of direct digital readout. Here, we developed dual-enhanced magnetobiosensors based on cascaded nucleic acid circuits, which integrate catalyzed hairpin assembly (CHA) with the hybridization chain reaction (HCR), for sensitive, portable and digital quantitative detection of circulating miRNAs in serum by a personal glucose meter (PGM).
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