Rhodium-mediated 18F-oxyfluorination of diazoketones using a fluorine-18-containing hypervalent iodine reagent

Geminal F-18-oxyfluorination of diazoketones was performed in the presence of rhodium mediators. The reactions were performed using a hypervalent iodine-based [F-18]fluoro-benziodoxole reagent. By this methodology various alpha-[F-18]fluoro ethers were obtained in high radiochemical yield (up to 98%) and molar activity (216 GBq mu mol(-1)).