期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 242, 期 -, 页码 685-689出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molliq.2017.07.067
关键词
Epirubicin; 1,3-Dipropylimidazolium bromide; CoFe2O4 nanoparticle; Anticancer drug
A suitable amount of CoFe2O4 nanoparticle (CoFe2O4/NPs) was used for modification of carbon paste electrode in the presence of paraffin oil and 1,3-dipropylimidazolium bromide (1,3-DPIBr) as binders. The modified electrode showed highly catalytic activity for electro-oxidation of epirubicin in biological condition. CoFe2O4 nanoparticle were synthesized by co-precipitation method with diameter of similar to 17.0 nm and characterized with XRD and TEM methods. The chronoamperometry method was used to evaluate diffusion coefficient (D-app) of the epirubicin in phosphate buffer solution pH = 7.0. A calibration curve with sensitivity (0.1426 mu A/mu M) was obtained for epirubicin in the concentration range 0.04-450 mu M at a surface of proposed electrode. Finally, the amplified sensor showed good ability of analysis of epirubicin in injection and serum samples. (C) 2017 Elsevier B.V. All rights reserved.
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