期刊
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
卷 11, 期 1, 页码 659-669出版社
WILEY
DOI: 10.1016/j.dadm.2019.08.006
关键词
Mild cognitive impairment; Dementia; Alzheimer's disease; Optical coherence tomography; Swept-source; Macula; Retina; Optic nerve; Retinal nerve fiber layer; Ganglion cell layer
资金
- PROQUALI/UFJF-Programa de Apoioa Qualificacao dos servidores da Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil [23071.000648/2019-66]
- CNPq-Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brasilia, Brazil [308172/2018-3]
Introduction: We compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment. Methods: Peripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire. Results: Most inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters. Discussion: The SS-OCT-measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
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