期刊
BIOENGINEERING-BASEL
卷 6, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/bioengineering6040107
关键词
PEG; PLGA; block copolymer; laponite; thermoresponsive hydrogel; nanocomposite; degradation; drug delivery; regeneration medicine; structural analysis
资金
- Leading Initiative for Excellent Young Researchers (LEADER)
- Japan Society for the Promotion of Science (JSPS
- KAKENHI) [19H00831]
- [18K13661]
- Grants-in-Aid for Scientific Research [19H00831] Funding Source: KAKEN
Thermoresponsive hydrogels showing biocompatibility and degradability have been under intense investigation for biomedical applications, especially hydrogels composed of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLGA) as first-line materials. Even though various aspects such as gelation behavior, degradation behavior, drug-release behavior, and composition effect have been studied for 20 years since the first report of these hydrogels, there are still many outputs on parameters affecting their gelation, structure, and application. In this review, the current trends of research on linear block copolymers composed of PEG and PLGA during the last 5 years (2014-2019) are summarized. In detail, this review stresses newly found parameters affecting thermoresponsive gelation, findings from structural analysis by simulation, small-angle neutron scattering (SANS), etc., progress in biomedical applications including drug delivery systems and regeneration medicine, and nanocomposites composed of block copolymers with PEG and PLGA and nanomaterials (laponite).
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