期刊
NATURE PLANTS
卷 5, 期 12, 页码 1250-1259出版社
NATURE PORTFOLIO
DOI: 10.1038/s41477-019-0548-z
关键词
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资金
- NSF [IOS-1546867, IOS-1856627, IOS1238142, IOS-1339194]
- Technical University of Munich-Institute for Advanced Study - German Excellent Initiative
- European Seventh Framework Programme [291763]
- Pew Charitable Trusts
Chromatin accessibility and modification is a hallmark of regulatory DNA, the study of which led to the discovery of cis-regulatory elements (CREs). Here, we characterize chromatin accessibility, histone modifications and sequence conservation in 13 plant species. We identified thousands of putative CREs and revealed that distal CREs are prevalent in plants, especially in species with large and complex genomes. The majority of distal CREs have been moved away from their target genes by transposable-element (TE) proliferation, but a substantial number of distal CREs also seem to be created by TEs. Finally, plant distal CREs are associated with three major types of chromatin signatures that are distinct from metazoans. Taken together, these results suggest that CREs are prevalent in plants, highly dynamic during evolution and function through distinct chromatin pathways to regulate gene expression.
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